You will find there's release of norepinephrine from your descending inhibitory bulbospinal neurons that binds to alpha-two-receptors in the dorsal horn to reduce afferent suffering transmission and create analgesia. Therefore, medicine like clonidine that target alpha-two receptors can impact the transmission of agony. Relates to clonidine: oral pill, oral https://www.proleviate.com/post/the-new-pain-killer-conolidine