Pentobarbital will lessen the extent or impact of zonisamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Not known. pentobarbital will reduce the extent or impact of nicardipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. pentobarbital will lower the level or influence of buprenorphine by impacting hepatic/intestinal... https://alcuinx333ylb1.blog4youth.com/profile