DNA ligases seal 5′-PO4 and 3′-OH polynucleotide finishes by means of 3 nucleotidyl transfer measures involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are important guardians of genomic integrity, and ligase dysfunction underlies human genetic disease syndromes. Crystal buildings of DNA ligases bound to nucleotide and nucleic acid substrates have https://andreib568pjc2.wikinstructions.com/user